Hepatitis E Virus (HEV) is a non-enveloped, single- stranded RNA virus identified in 1990. Infection with HEV induces acute or sub-clinical liver diseases similar to hepatitis A. HEV infections, endemic and frequently epidemic in developing countries, is seen also in developed countries in a sporadic form with or without a history of traveling to endemic area. The overall case-fatality is 0.5~3 %, and much higher (15~25 %) among pregnant women. A hypothesis that HEV infection is a zoonosis was presented in 1995.
Then a swine HEV and later an avian HEV were identified and sequenced separately in 1997 and 2001. Since then, HEV infection include anti-HEV, viremia and feces excretion of HEV was seen in a wide variety of animals, i.e., swine, rodents, wild monkeys, deer, cow, goats, dogs and chicken in both the developing and developed countries. A direct testimony was reported that the consumption of uncooked dear meat infected with HEV led to acute hepatitis E in human. And HEV genome sequences can be detected in pork livers available in the supermarkets in Japan. With the discovery of conformational epitopes in HEV, HEV serology was further explored and understood. The phenomenon of long-lasting and protective antibodies to HEV was observed which greatly enhance the understanding to the diagnosis, epidemiology, zoonosis-related studies and vaccine development.
¡¾DIRECTIONS FOR USE¡¿
Allow the test cassette, specimen, buffer and/or controls to reach room temperature (15-30°C) prior to testing.
1. Remove the test cassette from sealed pouch and used it as soon as possible. Best results will be obtained if the assay is performed immediately after opening foil pouch.
2. Absorb the sample with 25 μL dropper, then transfer 1 drop of serum/plasma (approx. 25 μL) to the sample well (S) of the test cassette.
3. Add 1 drop of buffer (approx. 40 μL) into the sample well (S) of the test cassette, start the time.
4. Read the results at 15 minutes; do not interpret after 20 minutes.
|
Cat. No. |
Product Description |
Specimen |
Format |
Kit Size |
Cut-Off |
Status |
|
IHE-302 |
HEV IgG/IgM Rapid Test Cassette |
S / P |
Cassette |
40 T |
See Insert |
CE |
